Dapagliflozin approved as new heart failure treatment

Cytokines as new treatment targets in chronic heart failure

Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs appear to have little influence on the overall cytokine network in chronic heart failure (CHF). Increased interest in anticytokine therapy has therefore evolved. Several small studies have used tumour necrosis factor (TNF)-alpha as a...

Diuretics as pathogenetic treatment for heart failure

Increased intracardiac filling pressure or congestion causes symptoms and leads to hospital admissions in patients with heart failure, regardless of their systolic function. A history of hospital admission, in turn, predicts further hospitalizations and morbidity, and a higher number of hospitalizations determine higher mortality. Congestion is therefore the driving force of the natural history...

Cardiac resynchronisation therapy--new treatment for heart failure.

Statins for heart failure: a potential for new treatment.

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, statins, are potent and widely used cholesterol-lowering drugs. Since the pathophysiology of atherosclerosis involves the uptake of modified low density lipoprotein (LDL) cholesterol, it has been generally assumed that the cholesterol-lowering effect of statins mediates the beneficial effects on atherosclerotic disease. Sever...

New Insights in the Diagnosis and Treatment of Heart Failure

Cardiovascular disease is the leading cause of mortality in the US and in westernized countries with ischemic heart disease accounting for the majority of these deaths. Paradoxically, the improvements in the medical and surgical treatments of acute coronary syndrome are leading to an increasing number of "survivors" who are then developing heart failure. Despite considerable advances in its man...